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Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B containing lipoproteins: anti-atherogenic role for paraoxonase-2

Graham et al., 2020)

Copper is a cofactor for lysyl oxidase (the enzyme that crosslinks collagen and elastin), superoxide dismutase (a critical antioxidant enzyme), and numerous other copper-dependent enzymes involved in tissue maintenance

A multi week project may involve repeated assay runs across days, and drift in reagent sourcing can complicate comparisons

Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of type 2 diabetes

Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism