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More promising, perhaps, are multi-target approaches that simultaneously enhance EAAT2 function and reduce oxidative stress, potentially offering a more robust neuroprotective effect [403]

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Although no NF-B inhibitors have been approved to the clinical treatment for MS, the beneficial effects of NF-B interference by a considerable number of natural components (e.g., piperlongumine and denanthin) have been suggested in basic animal studies (120, 121)

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There are many studies that have examined the link between antioxidants and inflammatory and oxidative pathways

In mice deprived of cysteine or placed on a no-Trp diet + BSO, we also detected a slight but consistent decrease in the expression of multiple genes associated with mitochondrial respiratory complexes