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Similar content being viewed by others Introduction Konzo is a neglected and irreversible paralytic neurological condition that predominately affects the legs of children and women of childbearing age in sub-Saharan Africa

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Graphic Abstract Access this article Similar content being viewed by others Abbreviations MAO: Monoamine oxidase PD: Parkinsons disease DA: Dopamine FDA: The food and Drug Administration TH: Tyrosine hydroxylase AADC: Aromatic amino acid decarboxylase DOPAC: 3,4-Dihydroxy phenylacetic acid HMV: Homovanillic acid DDC: Dopa decarboxylase DAT: Dopamine transporter COMT: Catechol-O-methyl transferase FAD: Flavin adenine dinucleotide MAOIs: MAO inhibitors SAR: Structureactivity relationship BHT: Butylated hydroxytoluene EWG: Electron-withdrawing group EDG: Electron donating group BBB: Blood Brain Barrier CNS: Central nervous system References Ball N, Teo W-P, Chandra S, Chapman J (2019) Parkinsons disease and the environment

Alternative pathway therapy for urea cycle disorders: twenty years later