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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

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Some people check and recheck their syringe five or six times before injecting, caught in a loop of doubt about whether they measured correctly

Atypical TN aims for control

Users report difficulty falling asleep (sleep onset latency increases by 20-40 minutes), lighter sleep, and earlier waking