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Hepatic stellate cells had upregulated NNMT expression and altered H3K27 methylation status, which affected the N6-methyladenosine (m6A) of CD44, consequently contributing to the formation of the splice variant CD44v3, which is closely related to tumor metastasis

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On paper, the combination addresses both sides of the energy balance equation through complementary mechanisms

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Contraindications include: Sulfa allergy, due to potential sensitivity to methionine derivatives