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Fracture healing phases: Inflammatory phase (0-7 days) creates hematoma, recruits inflammatory cells, releases cytokines and growth factors initiating repair

[Google Scholar] 327.Zaoui A., Cherrah Y., Mahassini N., Alaoui K., Amarouch H., Hassar M

Few lipid-filled adipocytes (arrowheads) remain

Moreover, melatonin activates pyruvate dehydrogenase kinase 4 (PDK4) to regulate acetyl-CoA content ( -oxidation or increasing the transfer of fatty acid-derived acetyl-CoA into mitochondria ( FIGURE 2 Second, melatonin can enhance the activity of the electron-transport chain (ETC) and oxidative phosphorylation (OXPHOS) to regulate mitochondrial metabolism

A few days later, the patient developed acute renal failure

When mitochondria are damaged or aged, cardiolipin becomes oxidized (peroxidized), causing cristae disorganization and impaired ETC function