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Some benefits particularly hormonal balance and reproductive support may take 2-3 months of sustained supplementation to become fully apparent

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The above-referenced case reports and series demonstrated that patients did not have clinical symptoms related to cardiomyopathy, and that severe, progressive, and/or fatal cardiomyopathy is unlikely in HT-1 patients

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Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death