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Improving these characteristics through medicinal chemistry is essential

The in situ thermosensitive hydrogel with adequate viscosity for intranasal administration was prepared with 90% (w/w) of fosphenytoin and 17% of poloxamer 407 (%, w/v), showing a droplet size of 219.7 26.8 nm, PDI of 0.237 0.040, ZP of 10.7 2.7 mV and osmolarity of 1375 mOsm/kg

Although diazepam belongs to benzodiazepines (BZDs) and zolpidem belongs to non-benzodiazepine also known as z-drug, they both bind to the BZD site of GABA A receptor

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A., Kim, M., Chen, R., Eidelberg, D., Gallea, C., Horn, A

However, quantification of neuronal 4HNE immunoreactivity by immunofluorescence only showed a trend to increase in CA1 Tg neurons (Fig