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Under oxidative stress conditions, BH 4 is swiftly oxidized to BH 2 by superoxide anions, particularly peroxynitrite generated by the scavenging of NO by O 2 , and BH 2 can subsequently be regenerated into BH 4 through the dihydrofolate reductase (DHFR) recovery pathway

They also found that the activity of the enzyme toward the gluten component gliadin, the primary source of immunogenic peptides, eliminated its ability to induce a T cell response in a cellular assay (8)

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