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Modulation of the immunosuppressive tumor microenvironment The BM niche in MM patients is intrinsically immunosuppressive, containing cells able to blunt the immune response and adenosine (ADO) that may lead to an anergic status of T, NK, and dendritic cells [10]

Although serum levels of ALT in the vitamin B12 group decreased significantly in the present study, this change did not reach a significant level compared to the placebo group

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