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RNF34 is a cold-regulated E3 ligase responsible for the ubiquitination of PGC-1, a master regulator of thermogenesis, and negatively controls brown fat cell metabolism (Wei et al

Iron accumulation from various sources significantly contributes to AS and vascular endothelial cell (VEC) ferroptosis

Schildknecht S, Pltl D, Nagel DM, Matt F, Scholz D, Lotharius J, et al

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Because a substantial portion of freshly generated ATP in glycolytic cells is partitioned to energetically costly processes like protein synthesis [71], glucose sensing and phosphorylation of GATOR2 by AMPK is likely coupled to blockade of the protein synthetic machinery even when amino acids are present