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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)

When an infection or another stress is quickly resolved, the HPA axis returns to its normal functioning, which consists in being poised to be activated and deactivated quickly

Clinical evidence for some benefits may be limited

This reciprocal amplification between OS and hormonal imbalance forms a pathological loop that sustains the metabolic-reproductive continuum of PCOS

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