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Sandstrom, J., Carlsson, L., Marklund, S.L

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Beyond TLR4/MyD88 inhibition, accumulating evidence indicates that dioscin exerts broader cytoprotective actions by attenuating oxidative stress and regulated cell death pathways, including ferroptosis, necroptosis, and apoptosis, through activation of Nrf2/HO-1 signaling, modulation of SIRT1/SIRT3-associated mitochondrial homeostasis, and suppression of inflammation-driven tubular injury (Zhang et al