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The mechanisms likely involve a combination of its anti-inflammatory properties and its core angiogenic action, which improves blood flow to the injured site and supports the survival of salvageable neurons

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MOTS-C: A Mitochondrial-Derived Peptide MOTS-C is a small peptide (16 amino acids) that is notable for being encoded within the mitochondrial genome, rather than the nuclear genome like most peptides and proteins

Kyere KA, Than KD, Wang AC, et al

When the concentration of the lipid peroxidation product 4-HNE is relatively low, it can augment IKB kinase (IKK) activity, promoting IKB phosphorylation

This modification impairs the binding of AGO2 to the mitochondrial membrane transporter TIMM17B, inhibiting the translocation of AGO2 to the mitochondria