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The suggestion is that reduced GR activity and therefore less 'reduced glutathione' may be implicated in Irritable Bowel Syndrome - possibly because it has less defenses against free radicals, the cause of oxidative stress

The natural levels of glutathione decline with age, stress, a poor diet, and exposure to environmental toxins

Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF, Hla T (2001) Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice

IGF, Insulin-like Growth Factor

Cross talk between alcohol-induced oxidative stress and HCV replication

To address this, antioxidants are increasingly incorporated into ART protocols