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321 Recognition-memory impairment in an AD mouse model (5xFAD) can be accelerated by high-fat obesogenic diet by increasing blood levels of the metabolite N-acetylneuraminic acid (NANA), which results in systemic immune exhaustion

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These findings demonstrate that LtAP1 may participate in ROS neutralization by activating the glutathione system

At excessive concentrations, breakdown may exceed synthesis