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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

Unopened product has a shelf life of 2 years from the manufactured date and should be kept in a cool, dry place away from sunlight

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It has been suggested to start tocilizumab early, in order to avoid mechanical ventilation [11], although the best timing for the treatment is still being investigated [12]