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For example, a defect in mitochondrial protein import or respiratory function can amplify cytosolic stress via reactive oxygen species and altered NAD+/ATP balance

doi: 10.1038/nature10152 93 LyonsRMKeski-OjaJMosesHL

Regular exercise also reduces systemic inflammation by lowering circulating levels of pro-inflammatory cytokines (e.g., TNF-, IL-6) and stimulating the release of anti-inflammatory myokines such as irisin and interleukin-15 from muscle, which promote lipid oxidation and vascular health (149)

Tsai HC, Han MH

After serum limitation-induction, positive FOXO4 and p53-pS15 immunofluorescence staining was stronger in the nucleus of keloid fibroblasts at 48 h, but in the nucleus of normal skin fibroblasts at 72 h

Ammons DT, MacDonald CR, Chow L, Repasky EA, Dow S