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POLG mutations in Alpers syndrome

Braz J Microbiol

For instance, Hevin promotes excitatory synapse formation by bridging neurxin 1 and neuroligin 1, whereas SPARC antagonizes this effect, thereby refining synaptic connections

1993;12:62-63 Rooyackers OE

SIN not only improves gut microbiota dysbiosis but also restores the intestinal barrier by increasing the expression of ZO-1, occludin, and BDNF, thereby reducing neuroinflammation in both the gut and the brain