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The one piece of cleaner support is Sun 2021 (PMID 34827486), an independent group's APP/PS1 mouse study reporting improved Morris water maze performance, increased synaptophysin, and reduced IL-1/TNF- via PI3K/AKT

The best-known early paper is a 2003 study reporting that Epithalon induced telomerase activity and telomere elongation in human somatic cells

Colon Rectum 33, 891901

In addition, iron (II) and (III) ions (Fe 2+ or Fe 3+ ), as part of the toxic structure of oxyhemoglobin in a free state, augment OS in the blood

[DOI] [PubMed] [Google Scholar] 138.Zhang C., Qiu C., Hu F.B., David R.M., van Dam R.M., Bralley A., Williams M.A

This is the closest human dataset informing IGF-1 LR3 risk