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When lung tissue homogenates were evaluated by Western analysis, GST pi was higher in Stage I-II COPD compared to healthy smokers (p = 0.002) (Figure 4A,B)

In massive overdoses, coma and metabolic acidosis may occur prior to hepatic failure

doi: 10.1016/j.physbeh.2007.10.010 366 SmithUKahnBB

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In the context of tumor immune microenvironment, these findings suggest that circadian disruption potentially increases NETs formation, which has been shown to interfere with anti-tumor T and NK cell cytotoxicity 121

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