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In 1996, Rozman identified the functional human CYP51A1 gene on chromosome 7q21.2-21.3 using DNA isolated from 19 somatic hybridization groups and a series of chromosome 7-specific yeast artificial chromosomes (YACs) [15, 16]

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A deficiency in vitamin B12 may cause tiredness, weakness, constipation, loss of appetite and megaloblastic anemia