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This rapid increase supports the maintenance of the corpus luteum, which in turn produces progesterone to sustain the uterine lining and support the developing embryo

Proc Natl Acad Sci U S A 116(30):1512215127

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Hence, therapeutic candidates that meet three criteria are likely to be the most promising: the macrophage-enriched expression, the reproducible mechanistic connection between the tumor-promoting expression of TAM phenotype and the ability to reverse immune suppression in vivo