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On a cellular level, PHD1 is predominantly expressed within the nucleus, whereas PHD2 can be found within the cytoplasm and PHD3 in both the nucleus and the cytoplasm [18,19,20]

Conclusions The antagonistic pleiotropy in the function of the insulin/IGF-1 pathway reveals a paradox of the aging process since insulin/IGF-1 signaling is an important signaling pathway of growth and differentiation during development but its function accelerates the aging process later in the lifespan

However, no controlled study has examined this combination in any species

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Many studies have shown that oral contraceptives reduce serum magnesium levels