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Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]

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This is of particular importance as PPAR deficiency inhibits neurodevelopment within zebrafish, and may therefore result in significant cognitive deficits in adulthood were it to be epigenetically silenced through diet [156]

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( m ) Representative flow cytometry plot showing Versican staining on BMDCs used in migration assays

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