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(J) NCI-H446 cells overexpressing PRMT5 were treated with C+E+Ana, with Ana being added from 0 to W8, and CD44 fluorescence intensity in SA--gal-positive cells was quantified on day W8 (scale bar: 100 m)

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Based on the above shortcomings, we have summarized the compounds that have been studied for structural modification, including shikonin, curcumin, oleanolic acid, alepterolic acid, neo-tanshinlactone and genistein, aiming to provide ideas for structural modification of natural products (Fig

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