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106,107 Preclinical studies have shown that potent in situ cancer vaccine regimens, such as those combining radiotherapy with intratumoral immunocytokines (e.g., hu14.18IL2) and immune checkpoint blockade (e.g., antiCTLA4), can induce endogenous tumor-specific IgG production and generate humoral immune memory not observed following surgical resection alone

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[DOI] [PMC free article] [PubMed] [Google Scholar] 275.Huseynov A., Akin I., Duerschmied D., Scharf R.E

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