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The most widely studied members of the FOXO subfamily are FOXO1 and FOXO3

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Since the level of -glutamyl-cysteine synthetase, the enzyme which is a rate limiting enzyme in the biochemical pathway of glutathione synthesis, is normal, the ratio stays high and induces a state of oxidative stress in the cells

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Cancer 13 , 5165 (2013)

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Ginger reduces IBD activity by targeting IL-17, IFN-, and TNF-, while increasing the anti-inflammatory cytokines IL-10, IL-22, and TGF- (236) ( Supplementary Table 1 )

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