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Indeed, in a recently completed Phase I trial of APR-246 in patients with haematological malignancies, it was noted that the addition of APR-246 to a patient receiving concurrent sorafenib resulted in complete remission of their acute myeloid leukaemia 35

[55] Variations in cholesterol metabolising genes such as the hepatic lipase, cholesterol ester transferase, lipoprotein lipase and the ATP-binding cassette A1 correlate with disease progression

In fact, the high expression of glycogen synthase-1 in RA-FLSs can lead to the excessive accumulation of glycogen and inhibit AMPK expression, leading to the high expression of matrix metallopeptidase (MMP)-1, MMP-9, IL-6, and CCL-2, along with increased proliferation and migration of FLSs

Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment

velutipes filtrates (14.86 0.55 mg GAE/g d.w.) but fivefold higher TPC in T

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