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Copper influences over 4,000 genes, acting as an epigenetic modifier that reverses age-related gene expression suppressing inflammatory genes and increasing expression of genes involved in tissue regeneration

In the prefrontal cortex, 5-HT2A hypermethylation demonstrated a bidirectional regulatory effect, influencing treatment efficacy while also being modulated by medication (Abdolmaleky et al., 2006)

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10.1074/jbc.M708402200 J

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Indican itself is not a sufficient marker to know what types of treatment may be needed, but it is an indicator that further work-up should be completed to understand what is happening in the gut