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10.1016/j.neuroscience.2014.11.025 26

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Raun K (1998)

doi: 10.3389/fnut.2024.1499697 106 ZhangFXuHXiaRYuPLiYYuXet al

Gallego, S

We further hypothesized that supplementation with these metabolic cofactors would promote mitochondrial fatty acid uptake and oxidation, and reduce hepatic fat and inflammation, Zeybel said, adding that the underlying mechanism in the pathogenesis of NAFLD is inadequate removal of hepatic fat by fatty acid oxidation