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Dorz S, Borgherini G, Conforti D, Scarso C, Magni G

Leung, M

In addition to neuron ferroptosis at the lesion site, SCI causes motor cortex atrophy and functional changes early in the disease, and motor neuron death is thought to be the cause of primary motor cortex atrophy after SCI

Through physical interaction with the latter, FOXO3 prevents NFkB from undergoing nuclear translocation, and thus attenuates NF-kB-mediated pro-inflammatory response 72

BPC-157 has also been shown to exert anti-inflammatory effects

For example, the PARP inhibitor olaparib disrupts the SDF-1/CXCR4 axis to impair MDSC recruitment, leading to superior tumor reduction when combined with EGFRvIII-targeted CAR-T cells (178)