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J Biol Chem (1998) 273(42):2710410

Melanotan II's lactam bridge between the Asp and Lys side chains constrains the peptide into a rigid cyclic conformation that dramatically reduces the conformational entropy penalty upon receptor binding, resulting in higher binding affinity at melanocortin receptors compared to linear analogs of equivalent sequence

The active ingredients work beneath the skin to dissolve fat cells without harming surrounding tissues

Minder EI, Barman-Aksoezen J, Schneider-Yin X

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