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The 2019 BPCIA framework restricts 503A compounding pharmacies to five categories: FDA-approved peptides, FDA GRAS, peptides with a USP monograph, peptides on the 503A Bulks List, and Category I interim Bulks List peptides

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(a) * * * (9) For the second and each subsequent performance year during the term of the agreement period, the ACO's benchmark is adjusted for the following, as applicable: For the addition and removal of ACO participants or ACO providers/suppliers in accordance with 425.118(b), for a change to the ACO's beneficiary assignment methodology selection under 425.226(a)(1), for a change to the beneficiary assignment methodology specified in subpart E of this part, for changes in values used in benchmark calculations as a result of issuance of a revised initial determination under 425.315, and for changes in values used in benchmark calculations as a result of the ( performance year being affected by significant, anomalous, and highly suspect billing under 425.672

Oral forms are more convenient but may have lower bioavailability for NAD+