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These data support the hypothesis that chronic cannabis use causes an increase in stress responses during CVS,21 and show that the variations in the endocannabinoid pathway lead to a higher risk of developing CVS

Control trials are missing in pediatric population

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Gorrindo, P

Another class of compounds, which bind to the N-terminal domain (NTD) of AR and disrupt its interactions (AR-NTD inhibitors) may be especially relevant to interfere with cell-type specific mediators of AR function 197