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New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics

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RSL3 binds to the nucleophilic active site of GPX4, and then reduces the expression level of GPX4 most effectively through chloroacetamide moiety (Jelinek et al., 2018), thus inactivating GPX4, producing lethal ROS accumulation and inducing ferroptosis

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