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Further validations in terms of specificity, sensitivity, and reproducibility in larger populations (including children as well) will be required for these new markers before applications in routine clinical practice

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doi: 10.1016/j.neo.2014.06.003

Should not be consumed by pregnant or breastfeeding women and children under 18 years of age

Bakalov 2020), skin rash (NatMed 2025, unclear, unknown grading), hypophosphatemia resolved after discontinuation (NatMed2025)

Diagnosing B12 deficiency is not easy