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The precise mechanism remains to be determined, although action on KCa 2+ channels in the outflow pathway has been suggested ( Dysfunctional Mitophagy Exacerbates Inflammation Mitophagy helps regulate mitochondria homeostasis by getting rid of dysfunctional mitochondria, and the inhibition of mitophagy results in the accumulation of damaged mitochondria and sometimes inflammasome activation

Published rodent protocols typically use subcutaneous or intraperitoneal injection in saline vehicle, dosed in pulsed courses (for example 1 g/kg daily for 10 days, repeated quarterly)

Fandrey J, Seydel FP, Siegers CP, Jelkman W: Role of cytochrome P450 in the control of the production of erythropoietin

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The activities of SOD and POD were also measured (Fig 7D and 7E) and the results showed no significant difference between transgenic and WT plants under normal conditions

Notably, conditioned medium from PAT of patients with CRC and MC38 tumour-bearing mice contained 124 M and 97 M KYN, respectively (Supplementary Table 3)