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May 1990

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Similar to other neurologic disorders that are considered neurodegenerative, such as amyotrophic lateral sclerosis (ALS), multiple sclerosis, Alzheimers disease (AD), Huntingtons disease, and Parkinsons disease, major psychiatric disorders, such as schizophrenia, depression, and bipolar disorder, also are neurodegenerative if left untreated or if multiple relapses recur because of treatment discontinuation ( Table )

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Nevertheless, although more of these inhibitors are likely to be developed, the issue of specificity may be a limiting factor for their safe and efficacious widespread use