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Therefore, restoring redox homeostasis can serve as a rational therapeutic strategy to alleviate OA progression

However, several studies also reported a lack of any effect of CoQ 10 supplementation on arterial lesions or endothelial function, despite decreased aortic lipid oxidation and increased resistance of plasma lipids to ex vivo oxidation (319, 321)

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Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability

Sugar-sweetened beverages consumption and the risk of depression: A meta-analysis of observational studies