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Remarkable enhancement in antibody titers and hormonal levels was observed within 3 months of therapy ( p 0.05) [48]

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Shortly after the original identification, the copper-binding role was established, and the conceptual framing shifted toward GHK as a copper-delivery peptide whose proliferation-supporting activity in the original assays reflected the role of copper in cellular biology rather than a direct growth-factor signaling activity in the classical sense