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Long-term use may be necessary for chronic conditions, but requires regular monitoring by a healthcare provider to manage side effects and effectiveness

This resistance is often associated with the upregulation of epithelial-mesenchymal transition (EMT), a process by which carcinoma cells acquire a mesenchymal-like phenotype, leading to increased invasiveness and metastatic potential (Rastegar-Pouyani et al

Further, uracil O 2 causes RNA binding whereas guanine and adenine N 7 atoms facilitate the binding to the backbone phosphate group

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Bibcode:2008EnvMM..49...16K