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The only reported limitation is that compound 18 is a P-gp substrate, which may limit its accumulation inside the tumors [92]

The amount of vitamin B12 you may need each day will vary depending on your age

Colonetti, et al

B12 helps your nervous system operate smoothly

Although vitamin B 12 deficiency is known to damage the myelin sheath covering cranial, spinal, and peripheral nerves, the biochemical processes leading to neurologic damage in vitamin B 12 deficiency are not yet fully understood (22)