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Sirtuins as regulators of metabolism and healthspan

Because the results above showed that the reduced dihydrolipoic moiety, but not the oxidized lipoic moiety, can react with RNS, we also included different combinations of substrates during the incubation to manipulate the redox state of the lipoic arm

Reilley, M

"Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia"

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

Romero-Haro AA, Figuerola J, Alonso-Alvarez C