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10.1016/j.celrep.2012.06.009 130 TretterV.JacobT

6 suggests that two substitutions (N74S and R121S) give rise to structural changes that reorient the copper-coordinating side chains of H451 and H453

The improvement in energy levels following B12 supplementation in deficient individuals reflects restoration of normal physiological function rather than a stimulant effect