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Since MLN4924 only affects cullin-dependent RING E3 ubiquitin ligases (Duda et al, 2008), but not RNF4, this data confirmed that CCW28-3 induced RNF4-independent degradation via a different but so far unidentified cullin-dependent RING E3 ligase

Rifaximin for small intestinal bacterial overgrowth in patients without irritable bowel syndrome

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McWilliams, R

and de Villartay, J-P

Additional information Peer review information Nature Communications thanks Alessandro Giuffr and the other, anonymous, reviewer(s) for their contribution to the peer review of this work