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Lyophilization followed by reconstitution demonstrated excellent activity retention, suggesting potential for improving long-term stability

44 described a case of statin-induced cholestasis in a 72-year-old man who had been treated with atorvastatin and developed nausea, jaundice, and scleral icterus with marked elevations of bilirubin (total bilirubin 22 mg/dL) and ALP (four times the ULN) and only marginal increases of aminotransferases

In a thrombotic mouse model, ADA-409052 administration significantly reduced cerebral infarction, cerebral edema, and pro-inflammatory factor levels [85]

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