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This might be related to ER stress, as KO mouse islets show a modest increase in Chac1 expression but no difference in beta cell identity genes

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doi: 10.1016/S0140-6736(72)90676-9 3 RuwendeCKhooSCSnowRWYatesSNKwiatkowskiDGuptaSet al

& Moneti, G

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[8] also reported elevated oxidative stress and inflammation in lipedema tissue, and our metabolomic data support the existence of a dysregulated redox environment potentially sustained by aberrant AKT1 activation