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GEM contextualization resulted in models with a number of reactions 8959, 8916, 8757, 8763, and 8761, respectively, for HIV-MNO, mock-MNO, HIV-NO, mock-NO, and HIV HI-NO

Wound Care (2020)

10.1179/147683008x301405 181 RochaC

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They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen

Consequently, 18 genic SNPs identified as significant MTAs were selected for haplotype construction