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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

Reyes et al

While research indicates that it does not significantly impact growth hormone levels, IGF-1, or glucose metabolism, long-term studies on its safety are still limited

Tomer Y, Davies TF